Staff Scientist – Aerosol drug delivery
Location: Boston, MA, USA
The Wyss Institute for Biologically Inspired Engineering @ Harvard
Duties & Responsibilities: The mission of the Wyss Institute for Biologically Inspired Engineering at Harvard University is to transform human healthcare and the environment by emulating the way nature builds. Developed as an alliance between Harvard and other premier academic and clinical partner institutions, Institute faculty and staff collaborate in high-risk, fundamental research and science-driven technology development. A major focus of the Institute is to translate the technologies developed by its faculty and staff into commercial products and therapies through collaborations with clinical investigators and establishment of corporate alliances. For more information, visit: http://wyss.harvard.edu/
The Wyss Institute for Biologically Inspired Engineering at Harvard University seeks a talented, enthusiastic and experienced individual to work as an in-vitro pulmonary aerosol delivery scientist, collaborating with Institute researchers and faculty. Reporting to the Lead Senior Staff Scientist of the Biomimetics Microsystems platform the successful candidate will focus on development and application of experimental laboratory techniques to simulate and study aerosol drug delivery to the lung and microfluidic lung chip devices from nebulizer and dry powder inhalers. He/she will conduct research identifying factors that influence aerosol transport to the lung-on-a-chip, and generating experimental data to validate computer simulation models of pulmonary drug delivery. The successful candidates will work in collaboration with an inter-disciplinary team of scientists and will have access to excellent experimental and analytical facilities. Responsibilities include leading the design of experimental procedures and protocols, sample preparation, and analysis. The successful candidate for this position will perform research and train team members in aerosol delivery-related experimental techniques. The candidate will also work in collaborative efforts with other researchers at the Institute across disciplines, Harvard University, collaborating institutions and industry partners. The chosen candidate for this position will contribute results for the preparation of protocols, presentations, grants, and technical reports.
Basic Qualifications: Bachelor of Science in Pharmaceutical science, Engineering Chemistry, Physics, Chemistry, Analytical Chemistry, Biology, or related field required. Minimum 2-5 years of experience within the pharmaceutical industry essential with a strong background in aerosol physics or related experience required.
Additional Qualifications Advanced degree preferred. Ph.D. or Masters degree in pharmaceutical science, chemistry, or related field, with strong experience in inhalation / respiratory product development, such as dry powder inhalers (DPI), solutions or suspensions for nebulization, and/or metered dose inhalers (MDI) preferred. Knowledge of aerosol performance testing, including cascade impaction (e.g. Next Generation Impactor (NGI), Andersen impactor), emitted dose, and dose content uniformity. Candidates should have hands-on experimental skills e.g. experience in aerosol instrumentation aerosol characterization. Experience with cell culture and in vitro systems is preferred. Knowledge of toxicity testing and assay development, pharmacokinetics and drug metabolism, drugs discovery and development process would be a plus. Proficiency with personal computers and applicable software packages (Microsoft Word, Excel) is a must. The candidate should have strong organizational and communication skills required to assist and collaborate with multidisciplinary groups of technology innovators and engineers, as well as biologists and clinicians, in a dynamic team environment. Ability to tackle multiple projects simultaneously in a dynamic team is essential. Extensive knowledge of the drug discovery and development process and experience mentoring students is preferred.