Jan 27, 2014 talk @ the Wyss: Developing and manufacturing micro-engineered products

Talk today on microengineered products from Dr. Erol Harvey, CEO of MiniFAB, today at the Wyss Institute at Harvard:

Developing and manufacturing micro-engineered products

Monday, January 27, 2014
3:30 – 4:30 PM
Room 521, Wyss Institute
3 Blackfan Circle, Boston, MA 02115

Micro-engineered products are finding applications in a number of global markets including lab-on-a-chip systems, microfluidics and point of care diagnostics. Dr. Erol Harvey, CEO of MiniFAB, will introduce the successes and challenges towards developing and commercializing such products. He will discuss examples of key product functionalities, fabrication techniques, integration strategies, manufacturing methods and applications. His talk will be followed by a Q&A session, open to the Wyss community.

For more information, please contact:
Guy Thompson, Staff Mechanical Engineer
guy.thompson@wyss.harvard.edu

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Dec 5 2013 Event: Innovations at the intersections of micro/nanofabrication technology, biology, and biomedicine

buevent 1024x268 Dec 5 2013 Event: Innovations at the intersections of micro/nanofabrication technology, biology, and biomedicine

Exciting event coming up on December 5th at Boston University on “Innovations at the intersections of micro/nanofabrication technology, biology, and biomedicine“.   Organized by Professor Xin Zhang, the speaker line-up is stellar!  See below for details and click here to register: http://www.cvent.com/d/l4qjgb/4W

Please join us at the Boston University Photonics Center on Thursday, December 5 for our 17th Annual Photonics Center Symposium. This year’s symposium, chaired by Professor Xin Zhang, will explore innovations at the intersections of micro/nanofabrication technology, biology, and biomedicine.Join us for a full day of speakers from academia and industry, who will lead the audience in photonics research exploration. An evening reception will follow.

Symposium Speakers Include:

  • Dr. Joanna Aizenberg, Harvard University
  • Dr. Stephan Anderson, Boston University Medical Center
  • Dr. Joseph Charest, The Charles Stark Draper Laboratory
  • Dr. Christopher Chen, Boston University
  • Dr. Patrick Doyle, MIT
  • Dr. Chih-Ming Ho, University of California, Los Angeles
  • Dr. Donald Ingber, Harvard University
  • Mr. Jason Kroh, CardioMEMS
  • Mr. Benjamin Schlatka, MC10

Please join us on Thursday, December 5, 2013 for the Photonics Center Symposium.

Seating is limited, so be sure to register early.

WHEN
Thursday, December 5, 2013 8:00 a.m.-6:30 p.m.

WHERE
The Boston University Photonics Center
8 Saint Mary’s Street, Room 906
Boston, MA 02215

Visit the Symposium Website: http://www.cvent.com/d/l4qjgb/1Q

Register: http://www.cvent.com/d/l4qjgb/4W

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Job board: Two job postings from the Wyss Institute @ Harvard

Just a quick note to remind job-seekers and employers that the fluidicmems.com job board is available to help everyone connect!  Most recently, the Wyss Institute at Harvard has two microfluidics-related openings available now for a Microdevice Engineer and Research Assistant.

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Workshop on Micro- and Nanotechnologies for Medicine July 29-Aug 2, 2013

2013 05 02 15 36 55 Workshop on Micro  and Nanotechnologies for Medicine July 29 Aug 2, 2013

And more cool events this summer: a workshop organized by the Khademhosseini lab, Wyss Institute, NSF and Brigham and Women’s on Micro and Nanotechnologies for Medicine.  Terrific lineup–see this link for more info and to register!  Thanks to Mehmet Dokmeci for the heads up.

Micro- and Nanotechnologies for Medicine: Emerging Frontiers and Applications

Cambridge, MA (USA) July 29 — August 2, 2013

The Khademhosseini Laboratory, National Science Foundation, Wyss Institute for Biologically Inspired Engineering, and Brigham and Women’s Hospital are delighted to host the “Micro- and Nanotechnologies for Medicine: Emerging Frontiers and Applications” workshop this coming summer. The advances in micro- and nanotechnologies are expected to open up new possibilities and applications in diagnostics, therapy, drug delivery and regenerative medicine. In this workshop, participants will acquire the fundamentals and advances in the field of bioMEMS, biomaterials and tissue engineering. Leading experts will present the latest advances in the development of novel micro- and nanotechnologies and address a range of different challenges that are of importance to biomedicine at the interface of engineering, medicine and biological sciences.

Workshop Announcement

Registration deadline: June 1st, 2013!

Venue: 65 Landsdowne Street, Partners Research Building Room 103, Cambridge, MA, 02139

Website: http://www.tissueeng.net/lab/BioMEMS_Workshop.php

Workshop Chairs: Ali Khademhosseini, PhD; Mehmet R. Dokmeci, PhD

Technical Program Chairs: Gulden Camci-Unal, PhD; Nasim Annabi, PhD

Invited Speakers:

  • Rashid Bashir, UIUC, IL
  • Fariba Dehghani, University of Sydney, Australia
  • Sara Heilshorn, Stanford University, CA
  • Esmaiel Jabbari, University of South Carolina, SC
  • David Kaplan, Tufts University, MA
  • Pep Pamies, Senior editor, Nature Materials, UK
  • Tom Webster, Northeastern University, MA
  • Peng Yin, Wyss Institute, MA
  • Babak Ziaie, Purdue University, IN
  • Hoaje Bae, Kyung Hee University, Korea
  • Jianjun Cheng, UIUC, IL
  • Utkan Demirci, Harvard Medical School, BWH, MA
  • Matt Gevaert, KIYATECH Inc., SC
  • Roger Kamm, MIT, MA
  • Hai-Quan Mao, John Hopkins University, MD
  • Joe Tien, Boston University, MA
  • Pamela Yelick, Tufts University, MA
  • John Zhang, The University of Texas at Austin, TX
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CLEO 2013: Lab-on-a-chip meets optics

cleo 2013 960x150 blue CLEO 2013: Lab on a chip meets optics

Thanks to Chris Myatt for a heads up on some interesting sessions he is organizing at the Conference on Lasers and Electro-Optics (CLEO) Conference in San Jose, June 9-14.  Some fantastic talks, including one from Valerie Ng who’ll be talking about end user perspectives — what do they really want to see?  Definitely worth checking out!

Monday, June 10, 13:30 — 15:30

AM3M • Symposium on Lab-on-a-Chip Applications: Lab on Chip I

Presider: Chris Myatt; Precision Photonics Corporation, United States

Salon III (Marriott San Jose)

AM3M.1 • 13:30 Invited Submission

Computational On-Chip Imaging Toward Telemedicine Applications, Aydogan Ozcan1; 1Electrical and Bioengineering Departments, University of California Los Angeles, USA. We review our recent work on computational on-chip imaging and its applications to telemedicine and high-throughput microscopy, including wide-field imaging of individual viruses on a chip

AM3M.2 • 14:00 Invited Submission

Smartphone Based Optical Detection of Kaposi’s Sarcoma Associated Herpesvirus DNA, Matthew Mancuso1, David Erickson2; 1Department of Biomedical Engineering, Cornell University, USA; 2Sibley School of Mechanical and Aerospace Engineering, Cornell University, USA. We create a smartphone accessory that is capable of optically reading out a detection reaction in a microfluidic chip and test it using a colorimetric reaction targeted at DNA from Kaposi’s sarcoma associated herpesvirus.

AM3M.3 • 14:30 Invited Submission

SMART (Shrink Manufacturing Advanced Research Tools), Michelle Khine1; 1University of California, Irvine, USA. Leveraging the inherent heat-induced relaxation of pre-stressed thermoplastic sheets, we pattern in a variety of ways at the large scale and achieve micro and nanostructures by controlled shrinking down to 5% of the original patterns.

AM3M.4 • 15:00 Invited Submission

Microfluidics Facilitated Genome Sequencing for Limited Number of Cells, Liang Zhao1, Xiannian Zhang1, Aaron M. Streets1, Yuhong Pang1, Fuchou Tang1, Yanyi Huang1; 1Biodynamic Optical Imaging Center (BIOPIC), Peking University, China. We develop a microfluidics-based single cell RNA-Seq transcriptome analysis technology to perform the library-prep reaction steps at nanoliter range within sealed chambers on-chip, eliminating potential contaminations and sophisticated manual handlings.

Monday, 10 June, 16:00 — 18:00

AM4M • Symposium on Lab-on-a-Chip Applications: Lab on Chip II

Presider: Chris Myatt; Precision Photonics Corporation, United States

Salon III (Marriott San Jose)

AM4M.1 • 16:00 Invited Submission

From Lab-on-a-Chip to Lab-in-the Body: Miniaturization of Diagnostic Tools, Axel Scherer1; 1California Institute of Technology, USA. Optical molecular diagnostic tools are rapidly shrinking, enabling miniature systems that can be used to continuously monitor health in the body. We describe our work on integrated photonic systems for this purpose.

AM4M.2 • 16:30 Invited Submission

Where the Rubber Meets the Road – Clinical Diagnostic Testing and New Technology, Valerie Ng1; 1Alameda County Medical Center/HGH, USA. Diagnostic test devices using new and emerging technologies must meet regulatory standards for clinical use. I will discuss these regulatory requirements emphasizing how test device manufacturers can meet the needs of the clinical laboratory.

AM4M.3 • 17:00 Contributed Submission

Optofluidic Electrical Manipulation of Individual Biomolecules with nm-scale Precision, Mohammad Soltani1,2, Jun Lin1, Summer Saraf1, Robert Forties1, Michal Lipson2, Michelle Wang1; 1Physics, Cornell University, USA; 2Electrical and Computer Engineering, Cornell University, USA. We design and demonstrate electrically controlled optical trapping of individual microparticles and manipulation of biomolecules with nm-scale precision for high throughput applications. This has been realized by integration of photonics, fluidics, and electronics, on-chip.

AM4M.4 • 17:15 Invited Submission

Second Generation Multiplexed Diagnostics with Silicon Photonics, Cary Gunn1; 1Genalyte, USA. No abstract available.

AM4M.5 • 17:45 Contributed Submission

High-Q Mid-Infrared Chalcogenide Glass-On-Silicon Resonators for Spectroscopic Chemical Sensing, Hongtao Lin1, Lan Li1, Yi Zou1, Sylvain Danto2, J. David Musgraves2, Kathleen Richardson2, Juejun Hu1; 1Department of Materials Science & Engineering, University of Delaware, USA; 2College of Optics & Photonics, University of Central Florida, USA. We fabricated and characterized high-index-contrast As2Se3 micro-disk resonators on silicon with a record loaded Q-factor of 105 at 5.2 μm wavelength. On-chip chemical sensing using cavity-enhanced infrared spectroscopy was demonstrated using the micro-disk device.

Tuesday, 11 June, 11:00 — 13:00

ATu1N •  Symposium on Lab-on-a-Chip Applications: Lab on Chip III

Presider: Chris Myatt; Precision Photonics Corporation, United States

Salon IV (Marriott San Jose)

ATu1N.1 • 11:00 Invited Submission

New Microfluidic Technologies for Accelerating and Enhancing Molecular Binding Processes in Cartridge-format Assay Systems, Daniel Laser1; 1Wave80 Biosciences, Inc., USA. No abstract available.

ATu1N.2 • 11:30 Contributed Submission

Hybrid Optofluidic Device for Fluidic Particle Manipulation and Detection, Joshua Parks1, Jungkyu Kim2,3, Lynnell U. Zempoaltecatl4, Damla Ozcelik1, Hong Cai1, Rich Mathies2, Aaron Hawkins4, Holger Schmidt1; 1School of Engineering, University of California Santa Cruz, USA; 2Chemistry, University of California Berkeley, USA; 3Mechanical Engineering, Texas Tech University, USA; 4Electrical and Computer Engineering, Brigham Young University, USA. Integrated fluidic control and optical detection are presented through the synthesis of microfluidic automata and optofluidic waveguides. Analyte mixing and fluid velocity are controlled on Automaton while optical detection is achieved via liquid-core ARROW waveguides.

ATu1N.3 • 11:45 Invited Submission

Lab on a Chip Fluorescence Measurements – from Single Biomolecules to Testing Standards, Samuel Stavis1; 1NIST CNST, USA. Faint fluorescent signals from within lab on a chip devices may be overwhelmed by autofluorescent background noise from nearby surfaces and bulk materials. This measurement challenge becomes increasingly relevant as plastic chips are commercialized and standardized.

ATu1N.4 • 12:15 Contributed Submission

Dynamic switching between microparticle buffering and dropping on a silicon nitride optofluidic microring resonator, Jiawei Wang1, Andrew W. Poon1; 1Photonic Device Laboratory, Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong. We demonstrate dynamic switching between microparticle buffering and dropping on a silicon nitride optofluidic microring resonator by polarization switching. We calculate the cavity-field-enhancement factor as an indicator to explain the transition between buffering and dropping.

ATu1N.5 • 12:30 Invited Submission

Red-emitting Substrates for Rapid Botulinum Neurotoxin Detection, James N. Herron1, Konrad Engelhardt1, Vald O’Mel1; 1University of Utah, USA. We report a new red-emitting molecular beacon for botulinum neurotoxin A suitable for inexpensive rapid assay formats. Reaction kinetics including parameters like Km and Vmax were evaluated in a fluorogenic assay using the BoNT/A light chain.

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Microdroplets in Action Symposium: Cambridge UK July 26 2013

symsm Microdroplets in Action Symposium: Cambridge UK July 26 2013

Droplets, droplets everywhere!  I just heard about this upcoming 1-day symposium on microdroplets organized by Chris Abell’s group in Cambridge UK with a nice roster of speakers.  Great to see the mix of industry and academia:

MICRODROPLETS IN ACTION SYMPOSIUM

Friday 26th July 2013, 9.30 am – 5.30 pm

Christ’s College, Cambridge, UK

“Microdroplets in Action” is a one-day symposium to bring together leading scientists working in the area of microdroplets. Microdroplets are small homogeneous droplets, typically generated in microfluidic systems. Each droplet is potentially a unique reaction chamber in which a discrete chemical or biological transformation can be carried out. Microdroplets provide a conceptually new platform for carrying out experiments in the physical and biological sciences. Research in this area involves device fabrication, droplet physics, surfactant chemistry and ultrasensitive detection methods. The field has developed rapidly in recent years with applications in chemistry, biology and material science. There is strong interest in the area in Europe, the USA and Asia and a growing number of companies are seeking to adopt the technology.

Speakers:

  • Professor Charles Baroud - Laboratoire d’Hydrodynamique, Ecole Polytechnique, Paris
  • Professor Jerome Bibette  - ESPCI, Paris, France
  • Professor Jonathan Cooper – University of Glasgow, UK
  • Tim Atkins – The Dolomite Centre Ltd,  Royston, UK
  • Dr Joshua B. Edel – London Centre for Nanotechnnology, Imperial College London, UK
  • Professor Piotr Garstecki – Institute of Physical Chemistry, Polish Academy of Sciences, Poland
  • Dr Darren Link – Raindance Technologies, USA
  • Sphere Fluidics Ltd – Cambridge, UK
  • Dr Yonghao Zhang – University of Strathclyde, UK

Location:

The Yusuf Hamied Theatre, Christ’s College, Cambridge UK.

Registration:

To register please visit:

http://onlinesales.admin.cam.ac.uk/browse/extra_info.asp?compid=1&modid=2&prodid=653&deptid=118&catid=376

Registration fees:

Academic participants GBP 75.00

Participants from industry GBP 100.00

This fee includes a full day of lectures, a buffet lunch and refreshments during breaks. It is non-refundable. However, substitutions may be made at any time.

This event is sponsored by the Engineering and Physical Sciences Research Council, The Dolomite Centre Ltd and Sphere Fluidics Ltd.

If you have any queries about this symposium, please email:

chem-udropadmin@lists.cam.ac.uk

Further information about the Cambridge Microdroplets Group is available at:

http://www-microdroplets.ch.cam.ac.uk/

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Boston University: Summer Translational Research Fellowship Announcement DUE 4/1/2013

Do you have an MD or PhD and are interested in developing point-of-care technologies for cancer?  Wondering what you’ll be doing this summer?  Here’s an exciting opportunity from the Center for Future Technologies in Cancer Care at Boston University.  Note the deadline is 4/1/2013 — still time to apply!

Summer Translational Research Fellowship Announcement Application Due 4/1/13.

Center for Future Technologies in Cancer Care (CFTCC) at Boston University (www.bu.edu/ftcc): Member of the NIH POCTRN Network

We are requesting applications for a Summer Translational Research Fellowship. One fellowship will be awarded this year. The period of the fellowship is negotiable, but should be completed between May and September 2013.

The Center: Technologies to enable cancer treatments in local clinics or as home care could significantly lower healthcare costs. Examples include but are not limited to targeted ultrasound and light-based treatments, tools for monitoring chemotherapy patients at home between treatments, novel drug delivery methods, diagnostics and mobile health strategies.

Purpose of the Fellowship: The fellowship is meant to support the development of a new technology in the area of point-of-care technologies for the treatment, screening, diagnosis or monitoring of cancer.  The fellowship will allow the Fellow to spend protected time on activities that are aimed at technology development and directed professional development (training) that will support applications for follow on funding.  Fellows are encouraged to propose multidisciplinary work during in the fellowship period.  Strong proposals will integrate clinical needs assessment with technological and engineering aspects, and will specifically focus on the challenges of devices meant for use at the point-of-care.   Fellows will be encouraged to apply for follow on funding through the CFTCC and other agencies and foundations or, if appropriate, to seek private funding.

Elligibility: Applicants must hold an M.D. or a Ph.D. in a relevant field. Post doctoral researchers are eligible only if their current funding mechanism allows them to accept additional funding.

Amount and Use of Funds: Funds up to $25,000 are available.  Funds can be used for salary support, prototype development, proof of concept experiments and/or field testing.  Fellows may use some of the funds to travel to Boston for meetings and work at the Center.  The CFTCC will offer assistance to the Fellow in the form of prototyping and early clinical assessment of the new technology, including advice regarding intellectual property and regulatory issues.

Timeline for this RFA:

Application Due Date: 1 April 2013

Notification: 1 May 2013

Fellowship Period (flexible): 15 May 2013- 15 August 2013.

Application Instructions:

Please use Arial 11 font, and 0.5 inch margins on all sides.  Preliminary data is allowed and encouraged. The application package should be no more than nine (9) pages total. Applications that do not meet the formatting instructions will not be read.

1. Cover Sheet The cover page with the requested signatures must be included (1 page).

2. Curriculum Vitae: The application should include a current NIH Biosketch (page limit 4 pages).

3. Description of the Technology: The applicant should describe the technology in no more than two (2) pages, including figures and references. A description of the proposed activity during the fellowship should be included. Metrics for success should be listed and discussed.  These may be listed in terms of milestones. Plans for follow on funding beyond the fellowship period should be addressed.

4. Description of CFTCC Involvement: The applicant should describe in no more than one (1) page how the proposed technology matches the mission of the Center and how the Center resources will contribute to the eventual translation of the technology.

5. Budget: A one (1) page budget describing how the fellowship money will be spent should be included. List all salaries, supplies, travel, etc.

Please submit the completed application as ONE PDF to hfawcett@bu.edu by 5 pm EDT 4/1/13.

This information is also listed at www.bu.edu/ftcc/funding-opportunities

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Revisiting CTCs: A Compilation of Commercial CTC Platforms

2013 02 21 20 51 17 Revisiting CTCs: A Compilation of Commercial CTC Platforms

A few days ago Abdur Rub, Head of the In Vitro Diagnostics Program at the Agency for Science, Technology and Research (A*STAR) in Singapore commented on a previous FluidicMEMS post on circulating tumor cells (CTCs).  He maintains a terrific compilation of commercial CTC efforts worldwide (shown above).  There’s a lot of commercial activity in the CTC space, and I suspect there may be even more companies out there—for example Rarecyte.  Abdur keeps the list updated, so this is a great site to check back with every so often if you’re following the CTC world.  Not only does he maintain this list, he also blogs.  Check it out here!

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Upcoming conference: BioMEMS 2013 April 16-18 in Cleveland

2013 02 18 02 47 42 Upcoming conference: BioMEMS 2013 April 16 18 in Cleveland

Just a quick post to let people know about the upcoming BioMEMS conference in Cleveland this April 16-18.  This is an industry conference and covers a range of interesting topics including wearable electronics, neural interfaces, clinical diagnostics, and more.  Check it out!

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Book Chapter in Microfluidic Diagnostics Methods and Protocols

MicrofluidicDiagnostics 211x300 Book Chapter in Microfluidic Diagnostics Methods and Protocols

Happy to announce the publication of Gareth Jenkins and Colin Mansfield’s new book, Microfluidic Diagnostics: Methods and Protocols is now available!  I contributed Chapter 5 “Overview of the Microfluidic Diagnostics Commercial Landscape” and it was a fun project to consider what information on commercialization might be useful in a book like this.  As the Springer website notes, this book goes beyond methods and protocols, with a bigger pictures of helping scientists further develop technologies toward commercialization.  From the Springer website:

Microfluidic techniques are becoming widely incorporated into medical diagnostic systems due to the inherent advantages of miniaturization. In Microfluidic Diagnostics: Methods in Molecular Biology, researchers in the field detail methods and protocols covering subjects such as microfluidic device fabrication, on-chip sample preparation, diagnostic applications and detection methodologies. The protocols described range from cutting-edge developments to established techniques and basic demonstrations suitable for education and training; from basic fabrication methods to commercializing research.

Section 1: Microfluidic Diagnostics: From the Classroom to the Boardroom

  1. Present Technology and Future Trends in Point of Care Microfluidic Diagnostics (Lawrence Kulinsky, Zahra Noroozi, and Marc Madou)
  2. Teaching Microfluidic Diagnostics Using Jell-O Chips (Cheng Wei T. Yang and Eric T. Lagally)
  3. Fundamentals of Microfluidics for High School Students with No Prior Knowledge of Mechanics (Vishal Tandon and Walter Peck)
  4. Measuring Microchannel Electroosmotic Mobility and Zeta Potential by the Current Monitoring Method (Chenren Shao and Don L. DeVoe)
  5. Overview of the Microfluidic Diagnostics Commercial Landscape (L. Kim)
  6. Practical Aspects of the Preparation and Filing of Patent Applications (Fiona Bessoth)
  7. Introduction to In Vitro Diagnostic Device Regulatory Requirements (Jonathan Day)

Thanks, Gareth and Colin, for the opportunity to be part of this project!

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